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ACROSS
1)  bite or chew on with the teeth
2)  informal or slang terms for mentally irregular
3)  a sign of something about to happen
4)  a serious (sometimes fatal) infection of rodents caused by yersinia ____is and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal


DOWN
1)  any gummy shapeless matter; usually unpleasant
2)  a town in western alaska on the southern coast of the seward peninsula; an important center of an alaskan gold rush at the beginning of the 20th century
3)  the smallest whole number or a numeral representing this number
4)  an established custom

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gnaw
loco
omen
pest